Which symptom suggests digoxin toxicity?

• A. Nausea and vomiting
• B. Constipation
• C. Headache
• D. Hearing loss

Answer: (A)

Nausea and vomiting are classic early signs of digoxin toxicity. Digoxin has a narrow therapeutic window, so even small increases in level can produce GI symptoms before more serious effects appear. These early gastrointestinal manifestations reflect the drug’s systemic effect and often prompt evaluation for potential toxicity. Headache can occur with many conditions and is not specific to digoxin toxicity. Hearing loss and constipation are not typical features of digoxin toxicity, making them less likely indicators. When digoxin toxicity is suspected, assess for GI symptoms, monitor heart rhythm for possible arrhythmias, and check digoxin level and potassium, since electrolyte imbalances can influence toxicity risk.