Which statement accurately differentiates dobutamine and milrinone in heart failure therapy?

• A. Dobutamine is a beta-adrenergic agonist that increases heart rate.
• B. Milrinone is a PDE-3 inhibitor that causes vasodilation.
• C. Both increase inotropy; dobutamine is a beta-agonist with tachycardia risk; milrinone is a PDE-3 inhibitor with vasodilation; both can cause hypotension and arrhythmias.
• D. Milrinone increases vascular resistance and reduces contractility.

Answer: (C)